Dental Health Is a Direct Connection to General Health

Not that long ago oral hygiene was not considered anything important to one’s overall general health. Dental health and oral hygiene is as important as other things in our body. Their proper functioning can avoid lots of complications and if a problem occurs, then many of the tasks be stopped.

Apart from adding up to your beauty and smile by maintaining your teeth, it is also important for your health as dirty and pale teeth can result in many complications like intestinal problems, stomach problems and more.

They can also look good and smell good, likewise if you have maintained them well. In order to look after your teeth well, your teeth be clean of germs and debris that can make them look faded and yellow. Your gums along with your teeth if perfectly healthy they should not bleed while brushing as unhealthy gums bleed as well as hurt. So, if your gums and teeth are in perfect health they won’t bleed, hurt or have any bad breath.

Brushing and Cleaning

Proper brushing is the fundamental step to take to have clean and healthy teeth. There are many people who are not aware of the basic steps in cleaning and brushing teeth. Brushing requires 2 minutes time and it is important that at least this amount of time is given. You should reach with the toothbrush all areas of your mouth and brush all the teeth, paying special focus on back teeth, corner teeth, around the gum-line teeth etc.

Teeth cleaning and brushing helps you to clean your teeth off debris, plaque and bacteria and to make them look shiny, sparkling and white. Brushing the teeth right means brushing up and down and not long site of teeth and gums. The up and down movement with the brush will allow the bristles of the brush in between the teeth to remove any food particles. This will prevent many teeth ailments like gingivitis, cavities or dental caries, periodontal ailments etc.

Toothpaste!

Selecting toothpaste at random is a problem and a health concern. Chemicals in toothpaste make many people sick, most of the time not realizing the connection. There be hardly any toothpaste you can find of the shelf that are chemical free.

To find a toothpaste that is one hundred percent free of artificial flavor, color, sugar, sweetener, and toxic chemicals would be almost as hard as picking the winning lotto numbers. There is one well-known brand name made in China; this one is even worse than most of the others. Stay well clear from it. Most people are not aware of chemical sensitivity and those with allergies, diabetes etc. what effect this can have.

Dental Health Does Affect General Health

Most of us understand that poor dental health can cause gum disease, gingivitis, mouth sores, buildup of plaque and tooth loss. It doesn’t stop here; bad oral hygiene can lead to many other serious health issues. We should not underestimate, oral health is about much more. It can cause cardiovascular disease and blood disorder. Bacteria from the mouth can get into the blood stream, cause infection spreading throughout the body. Infection of the gum can interfere with brain cells and lead to memory loss.

Because of inflammation caused from gum disease, this can trigger rheumatoid arthritis, which is painful and is a debilitating inflammatory disease. As well it can affect kidneys, blood pressure, bones and weaken the immune system. As bacteria travels through the bloodstream, it can cause respiratory infection and infect lungs causing bronchitis and pneumonia.

Some other studies and information claim that cancer is also triggered by root canal. Evidence shows when cancer patients get the root-canal removed the recovery rate, when treated for cancer, is by far greater and the patient gets better. Although, the cause of the problem shouldn’t be ignored and treated first, before treating the symptom. As with oral health, it’s a well-known fact that oral health affect’s much more than just your mouth. Inflammation in the gums or toxic pockets in the jaw can destroy the immune system almost completely.

Clinical Trial Budgeting and Technological Impact

The current clinical trial and drug regulatory process have lagged behind advances in scientific research. Regulatory approval is based on the evidence of efficacy and safety gathered from pivotal trials. Most experts agreed that traditional approach to drug development constitute a blunt tool where a more focused experiment could suffice instead of a one-size-fits-all approach which is ineffective and wasteful.

According to studies conducted by New England Journal of medicine, almost nine in ten clinical trials do not meet FDA requirement and thus do not reach the market. Project fails when they do not meet endpoints. Lack of efficacy and complex protocol are the major cause of failure. To reverse this trend, productivity must be directed towards the poor predictive capability of the current experimental model.

Clinic trial plays a major role in drug development and advancement in technologies such as drug positioning, therapeutic target, and drug efficacy prediction are helping researchers and pharmaceutical companies in drug development.

Traditional trials have fixed parameter that is determined in advance and remain constant throughout out the process. One promising approach to modernizing clinical trials and maximizing efficiency is by adaptive trials which allow for certain parameters such as sample size and treatment regimen to be modified or replace on interim results.

The major hurdle is that investment in clinical research is dwindling as government and stakeholders tightened their budgets. As major sponsors revenue stabilize and cost continue to rise, the clinical trial finds itself in a financial squeeze. Pharmaceutical and medical-device companies have been intent on trimming budgets. Lean contract negotiations are the norm these days, no sponsor is walking around with money burning hole in their budget and most are responding to mandate to save cost by requiring CROs to provide unrealistic competitive budgets which are disastrous. With tightened budget, short-sightedness has become the order of the day and as a result, both sponsors and CROs reputation suffered.

Cutting back drastically or unwillingness to adequately fund a project will produce a poor result. This simplistic strategy is unrealistic and unsustainable. It is important to note that focusing solely on short-term strategy will be detrimental in the long-term. If sustainable research climate is created, prosperity will definitely grow.

There has been increasing effort in utilizing technologies to streamline protocol and boost efficacy in clinical research. The use of technology is empowering research professionals by helping them to make a decision based on resulting data. With the aid of technology, organizations are reducing cost and speeding up evaluation process. Technology allows for accrual of data faster and that information can be disseminated in real time. This can lead to a better decision being made on protocol, patient recruitment, and trial sites.

Here is the list of technologies impacting clinical trials today

Risk Based Monitoring (RMB)

Companies use risk based monitoring to target and prioritize resources, identify risks relating to quality, safety of subjects and integrity of clinical trial data. Risk based monitoring (RMB) can incorporate targeted monitoring or triggered monitoring and reduced source document verification (SDV).

Traditionally, source data verification (SDV) were conducted 100% via on-site monitoring, a labor intensive approach. Reduced SDV limits the measure of SDV at the site, study and subject level.

The quest for more key ways to manage clinical trials has distinguished risk based monitoring which attempts to manage resources without compromising on clinical quality.
The variables of protocol compliance, data integrity, and patient safety etc. impact how assets are deployed.

The impact of technology in risk based monitoring is profound and currently in markets are clinical trial management systems (CTMS) and remote data capture (RDC) which can support risk based monitoring system. Some systems still support manual entering and reporting of clinical trial data, for this reason, there is a need to setup more robust systems for flagging and alerting data automatically, these alerts can be developed for notifying those who need to act when an issue arises.

According to Medidata, the cost of onsite monitoring is approximated at 28.7% of study budget and project management at 26.47%. In moving to RMB, monitors can spend their time more judiciously and reduce cost.

Electronic Trial Master File

In biopharma industry, every organization involved in clinical trial maintains a trial master file containing several thousand pages of regulatory documents needed for each clinical trial.

Using a paper-based or hybrid trial master file system to manage thousands of clinical documents, processes and tasks can be overwhelming and can cause errors or misread that can ruin clinical trial and put it at risk for noncompliance.

Organizations usually employed an Enterprise Content Management System (ECM) to manage clinical trial regulatory documents. The ECM based eTMF offers automated methods to index, archive, and report on documents and content.

To eliminate paper from a clinical trial study, electronic signing utilizing digital signatures from verified users is being employed. Globally, most countries including the US and many countries in EU are accepting digital signatures in place of wet signatures thereby eliminating the need for scanned documents.

An electronic trial master file (eTMF) offers a robust platform to document management which allows study team members to gain a quick insight necessary to efficiently manage clinical trials and speedup time to market. Electronic document management processes are being adopted at a steady pace as it becomes vital to business productivity, shortened biopharma product development timelines, and cost cutting.

eSource

In 2013, the FDA release its Guidance Document on Electronic Source Data in Clinical Investigations, since then sponsors and study sites have been adopting and employing eSource as a method of recording data in clinical trials.

The definition of electronic source (eSource) is a clear concept — to capture or process source data electronically, this data exclude the source data that was captured on paper and transcribed into an electronic database. In eSource, the source data element itself must be electronic.

The benefit of eSource is apparent and the FDA endorsed it because it will be useful in: facilitating real-time entering of electronic source data during subject visits, removes the need to duplicate data, allows for accuracy and completeness of data by using electronic prompts for inconsistent and missing data and lessens the chance for transcription errors.

The need to modernize and streamline the way data is collected are evolving, as a result, much of the exploratory done thus far by several pharmaceutical companies have been mostly to build internal competency. In moving forward, it is critical that standards and interoperability within different eSource modalities come together to help create systems that provide accurate data in clinical research.

Using Clinical Data Repository (CDR) to drive optimization

The ability to effective manage, report and analyze data is of paramount importance in clinical trials. The major hurdle is that data from clinical trials are frequently entered by clinicians electronically or manually across multiple channels including EDC, LIMS, CDMS and IVRS and other systems each with unique underpinning needs. This approach causes data to end up in different databases making it complex and time-consuming to leverage and synchronize the data.

There is confusion as to what constitute or defines CDR as distinct from a clinical data warehouse (CDW). CDR can be thought of as consolidated storage and transfer of data for clinical trials including security, workflow, and systems for performing daily task all under one umbrella.

Centralization of the storage and management of data results are the purpose of CDR and to provide a steadfast and reliable infrastructure that supports clinical data analysis and management, facilitate standardization and secure transfer of data, allow for analytics and cross-trial analysis and to leverage data from trials across the pipeline.

5 Things You Should Definitely Know About Lactose-Free Milk

Ever heard about lactose-free milk? What exactly is it? You can miss out on some pretty serious nutrients if you are intolerant to lactose.

In short, lactose is a sugar which is found in almost all milk products. An enzyme called lactase should be present in the human body for the digestion of the sugar. In the small intestine, heavy sugars are split into simpler sugars and digested with the help of lactase. People who have a low amount of lactase in their body aren’t able to digest the heavy sugar and thus are intolerant to lactose. When they consume this sugar, it reaches their large intestine in an unchanged form and thus it becomes difficult to digest it.Approximately 70% of the world’s population suffers from lactose intolerance and it affects mostly adults.

Does this mean, that these people should completely stop consuming it? If people stop consuming such an important nutrition source, they would be unable to obtain all the important nutrients through a single source. This is where the milk for lactose intolerant come in. It is very beneficial for lactose intolerant people who can substitute their dairy products with products which contain low sugar contents. Let’s take a look at five things you should know about the milk for lactose intolerant.

How is it prepared

For those who are intolerant to dairy sugars, consumption of dairy products can cause stomach cramps, vomiting, diarrhoea, headaches, etc. But this doesn’t mean that they should just cut out the primary source of nutrition from their diet.

Reputed brands have come up with variants in milk to solve this problem- Milk for lactose intolerant. Unlike the name suggests, is not milk free from all lactose content. It is highly impossible to drain out all the complex sugars from dairy beverages. During the manufacturing, milk undergoes certain processes which split lactose in sugars like glucose and galactose. These are simple sugars and are easier to digest. No other nutrients other than the sugars content changes and thus enables people intolerant to dairy sugars to receive their daily dose of nutrients.

Extended shelf life:

The shelf life of this dairy product is longer than the regular milk. It is ultra pasteurised to elongate the shelf life. It undergoes a very high temperature for a short period of time which elongates the life of the product. As the demand for these types of milk variant is very less compared to the regular ones, the product is supposed to have a longer life.

Taste:

The dairy product is sweeter in taste as simple sugars taste sweet on your tongue. This is because of the complex sugars been broken down into two simple sugars- glucose and galactose. Simple sugars taste sweeter compared to the complex sugars. The taste is also slightly refined.

Nutritional benefits:

As we mentioned earlier, many people suffer from the intolerance of these sugars, lactose-free milk can help prevent the symptoms it causes. The older you get, the lesser is the lactase production in the body. Mostly, the countries which do not consume dairy products on a regular basis face these problems. Though it doesn’t cause very serious illnesses, avoiding the consumption of products with dairy sugars is the only solution.

Generally, it is rare for babies to develop lactose intolerance. A baby’s body generates lactase which helps in the digestion of complex sugars. In babies, lactose intolerance is more common in the ones who were prematurely born. Thus, there also is milk for babies which contains a low level of sugars. This helps the mothers around the world to give the right nutrients to their babies. Body decreases the generation of lactase as the child grows, hence, rather than milk with low lactose for babies, it can be opted for kids.

Non-dairy Alternatives:

There are many non-dairy alternatives, now, which does not contain cow’s milk. They are prepared from soybeans, almonds, etc. These do not contain the exact nutrition which cow’s milk provide but it is very beneficial for people suffering from lactose intolerance.

Consuming lactose-free milk is all the easier now because you do not have to walk down to stores looking for the products. In today’s world, when you can order anything at just one click, buying lactose-free milk online is also pretty easy. You can buy it from various sites which provide you with groceries and products which are required in day to day life- like the dairy products. You can just find a trusted source and order dairy products online. There are many online dairies which provide you with this product.

Thus, to answer our initial question, you do not have to miss out on your daily nutrition dose if you are lactose intolerant. There is milk for lactose intolerant people. Milk contains essential nutrients and it is recommended that everyone should include it in their daily diet. These sugars are not only included in milk but also in all other dairy products like cheese, curd, yoghurt, etc. Just read the precautions on the packs before consuming the product. Eat right! Stay healthy!